Évaluation de l'effet sur la santé : approvisionnement en eau, assainissement et hygiène

Réunion: International Workshop on Measuring the Health Impact of Water and Sanitation Programmes, 1983, Cox's Bazaar, BDCo-édité avec Unicef et ICDDR,

Malaria eradication within a generation: ambitious, achievable, and necessary

Where once the notion of malaria elimination at the regional level seemed beyond reach, the international discussion has now turned to an even loftier goal—the complete global eradication of malaria. Despite increased investment, technological improvements, and a massive reduction in deaths annually, arriving at consensus around the feasibility and the path to achieving malaria eradication has been difficult. The Lancet Commission on malaria eradication provides such a path. In the first report of its kind and with a bold vision, the Commission lays the out the necessary steps, including an even greater financial outlay, strengthening malaria programmes and global leadership, and acceleration of research and development, to eradicate malaria within a generation

Identification of Plasmodium vivax Proteins with Potential Role in Invasion Using Sequence Redundancy Reduction and Profile Hidden Markov Models

BACKGROUND: This study describes a bioinformatics approach designed to identify Plasmodium vivax proteins potentially involved in reticulocyte invasion. Specifically, different protein training sets were built and tuned based on different biological parameters, such as experimental evidence of secretion and/or involvement in invasion-related processes. A profile-based sequence method supported by hidden Markov models (HMMs) was then used to build classifiers to search for biologically-related proteins. The transcriptional profile of the P. vivax intra-erythrocyte developmental cycle was then screened using these classifiers. RESULTS: A bioinformatics methodology for identifying potentially secreted P. vivax proteins was designed using sequence redundancy reduction and probabilistic profiles. This methodology led to identifying a set of 45 proteins that are potentially secreted during the P. vivax intra-erythrocyte development cycle and could be involved in cell invasion. Thirteen of the 45 proteins have already been described as vaccine candidates; there is experimental evidence of protein expression for 7 of the 32 remaining ones, while no previous studies of expression, function or immunology have been carried out for the additional 25. CONCLUSIONS: The results support the idea that probabilistic techniques like profile HMMs improve similarity searches. Also, different adjustments such as sequence redundancy reduction using Pisces or Cd-Hit allowed data clustering based on rational reproducible measurements. This kind of approach for selecting proteins with specific functions is highly important for supporting large-scale analyses that could aid in the identification of genes encoding potential new target antigens for vaccine development and drug design. The present study has led to targeting 32 proteins for further testing regarding their ability to induce protective immune responses against P. vivax malaria

Moving towards true integration

Considerable action will be needed to get maximum benefits from the lessons learnt about integrated health car

Evaluating health impact : water supply, sanitation, and hygiene education

Meeting: International Workshop on Measuring the Health Impact of Water and Sanitation Programs, Nov. 1983, Cox's Bazaar, BDCopublished with UNICEF and the International Centre for Diarrhoeal Disease Research, Banglades

Evaluando el impacto en salud : agua, saneamiento y educación sanitaria

Reunión: International Workshop on Measuring the Health Impact of Water and Sanitation Programmes, Nov. 1983, Cox's Bazaar, BDPublicado conjuntamente con Unicef e ICDDR,BPublicado en Inglés bajo el título: Evaluating health impact : water supply, and hygiene educatio